Today's public recognition of outstanding talent in the male is more than as good as the same age of young women. Where are those women when they became adults? Reading excellent math-science talented women's biography at home and abroad, we can know the spirit of Maria Sklodowska-Curie is the math-science study of gifted women, representing of youth, and led them to the mental changes and their supports which are affecting these women in math-science gifted career development of an important promoter. How do outstanding math-science talented women achieve contributing to the world? This article provides the cumulative results of the current study with a view to learn more math-science talented women how they could do it. We are glad to open the door and turn on the light for future generations.