In April 2003, a chemical tracker happened to crush in Wu-Chi Taichung County. This traffic accident lead to leakage of large amount of acrylonitrile, and large scale of human exposure. This event revealed the shortage of antidotes storage and the unfamiliarity of emergency response. In fact, it is still unsettled how to treat acrylonitrile poisoning. The effects of potential antidotes were still in debate. Here, we reviewed the literatures and tried to propose the principles of management for the future occurring of mass acrylonitrile exposure.