This study assessed the bone mineral density (BMD, g/cm^2) in patients who had undergone breast cancer treatment. Seventy women without metastasis (aged 39-79 years; mean age, 53.0±8.0 years) and ninety-one controls (aged 34-72 years; mean age, 54.5±8.7 years) were recruited. The BMD of the lumbar spine (L1-L4), femoral neck, trochanter, Ward's triangle and hip were measured by Dual-energy X-ray absorptiometry (DXA). Anthropometric and lifestyle data were collected by direct interview using a structured questionnaire. The analytical results indicated that bone loss at all sites did not significantly differ between post-treatment subjects and controls. Conversely, bone loss at the femoral neck and Ward's triangle tended to exceed that at the lumbar spine and trochanter 10 or more years after treatment, especially in the Ward's triangle (p<0.05). In terms of lifestyle, hip BMD was significantly higher among patients who had previously undergone HRT, but excessive exercise and smoking corresponded with lower hip BMD (p<0.05). Lumbar spine BMD was more effective than other measured sites for calcium supplement, but the difference was not statistically significant (p>0.05). Bone mass index (BMI, kg/m^2) and BMD for trochanter and hip were positively correlated (p<0.05) due to the effect of risk factor on BMD. At all sites, age at first pregnancy and age at menopause were not associated with BMD (p>0.05). This study demonstrated that post-treatment patients do not suffer serious bone loss, but would not disregard that BMD is rapidly after 10 years of treatment. In conclusion, the finding of this study suggests that moderate exercise and regulation of body weight can minimize bone loss.
This study assessed the bone mineral density (BMD, g/cm^2) in patients who had undergone breast cancer treatment. Seventy women without metastasis (aged 39-79 years; mean age, 53.0±8.0 years) and ninety-one controls (aged 34-72 years; mean age, 54.5±8.7 years) were recruited. The BMD of the lumbar spine (L1-L4), femoral neck, trochanter, Ward's triangle and hip were measured by Dual-energy X-ray absorptiometry (DXA). Anthropometric and lifestyle data were collected by direct interview using a structured questionnaire. The analytical results indicated that bone loss at all sites did not significantly differ between post-treatment subjects and controls. Conversely, bone loss at the femoral neck and Ward's triangle tended to exceed that at the lumbar spine and trochanter 10 or more years after treatment, especially in the Ward's triangle (p<0.05). In terms of lifestyle, hip BMD was significantly higher among patients who had previously undergone HRT, but excessive exercise and smoking corresponded with lower hip BMD (p<0.05). Lumbar spine BMD was more effective than other measured sites for calcium supplement, but the difference was not statistically significant (p>0.05). Bone mass index (BMI, kg/m^2) and BMD for trochanter and hip were positively correlated (p<0.05) due to the effect of risk factor on BMD. At all sites, age at first pregnancy and age at menopause were not associated with BMD (p>0.05). This study demonstrated that post-treatment patients do not suffer serious bone loss, but would not disregard that BMD is rapidly after 10 years of treatment. In conclusion, the finding of this study suggests that moderate exercise and regulation of body weight can minimize bone loss.
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