This study examined the mediating effects of health-related help-seeking behaviors on stressful life events, numbers of health problems, psychiatric care activities and psychological well-being among primary caregivers of adolescent psychosis. A sample of ninety-three caregivers (M=47.7 years) was recruited from mental hospitals. Data was collected by structured questionnaires and interview. Hierarchical regression was used to examine the mediating effects of health-related help-seeking behaviors. The results indicated that 28.3% (p<.001) of the variance in the psychological well-being of caregivers could be explained by varying stressful life events, the number of health problems and health-related help-seeking behaviors. Moreover, health-related help-seeking behaviors substantially attenuate the adverse effects of stressful life events and health problems on psychological well-being. According to SAS Sobel analysis for health problems, the mediating effect of health-related help-seeking behavior was 25.39% (p=.017); for stressful life events, the mediating effect of health-related help-seeking behaviors was 24.67% (p=.033). The findings suggest that interventions which reinforce health-related help-seeking behaviors may assist caregivers in coping with stressful life experiences and chronic health problems and promoting their psychological well-being.