疑似罹患冠狀動脈疾病中年女性高敏感度C-反應蛋白影響因素之探討

The Related Factors of High-Sensitivity C-Reactive Protein in Middle-Aged Women with Suspected Coronary Artery Disease

蔡青青(Ching-Ching Tsai) ； 謝敏雄(Ming-Hsiung Hsieh) ； 王烱中(Giueng-Chueng Wang) ； 楊弘宇(Hung-Yu Yang) ； 鄭綺(Chii Jeng)

《新臺北護理期刊》 17卷2期 (2015/09) Pp. 11-23

https://doi.org/10.6540/NTJN.2015.2.002

摘要

背景：高敏感度C-反應蛋白（high-sensitivity C-reactive protein, hsCRP）是女性罹患冠狀動脈疾病（coronary arterydisease, CAD）重要的危險因素，就女性而言，其影響因素之先前研究結果並不一致。目的：本研究目的在探討疑似罹患CAD中年女性影響hsCRP值之相關因素。方法：採橫斷式研究，選取128位疑似CAD等待心導管檢查中年女性，於心導管室進行檢查前抽取血液進行分析，依照hsCRP血中濃度分為兩組（≦3、＞3mg/L）。以填寫問卷、查閱病歷、血液檢驗方式收集資料。結果： 整體平均56.9±5.7歲，23位（18%）病患hsCRP血中濃度＞3 mg/L。hsCRP＞3 mg/L組較多病患有腎功能不全病史、使用利尿劑、血管狹窄數目多、身體不活動情形。控制干擾因素後，身體不活動是hsCRP有意義的預測因子。身體不活動者發生高hsCRP的機率是有活動者的3.8倍（P＝0.01）。結論：身體不活動與高hsCRP有顯著相關性，中年女性應維持身體活動以減輕炎症反應，進而防治CAD。

關鍵字

高敏感度C-反應蛋白 ； 女性 ； 中年 ； 身體活動

並列摘要

Background: High-sensitivity C-reactive protein (hsCRP) is a key risk factor in coronary artery disease (CAD) in women; however, previous studies yielded inconsistent results regarding the influencing factors that affect women. Purpose：The purpose of this study was to explore the related factors of hsCRP in middle-aged women who were suspected of having CAD. Methods：This was a cross-sectional study, and 128 middle-aged women who were suspected of having CAD and were waiting for catheterization were recruited. Blood was collected to conduct analyses during catheterization procedures. Patients were divided into 2 groups based on their hsCRP blood levels (≤ 3or ＞ 3 mg/L). Data were collected from completed questionnaires, medical records, and blood test results. Results: Overall, the average age was 56.9±5.7 years, and 23 (18%) exhibited an hsCRP level of ＞ 3 mg/L. Patients who were classified into the hsCRP level of ＞ 3 mg/L group had a history of renal insufficiency, had used diuretics, possessed a high number of stenotic blood vessels, and were physically inactive. After controlling confounding factors, physical inactivity was a significant predictor to the hsCRP level. Patients who were physical inactivity possessed a 3.8-fold higher probability of exhibiting higher hsCRP levels than patients who were active (P = 0.01). Conclusions：Physical inactivity was significantly correlated with high hsCRP levels. Middle-aged women should maintain physical activity to reduce inflammatory reactions, thereby reducing the risk of CAD.

並列關鍵字

High sensitivity C-reactive protein ； Women ； Middle aged ； Physical activity

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