Background and Purpose: A 64-year-old male was admitted to a regional teaching hospital due todizziness in November 2016, diagnosed with lung adenocarcinoma and accepted thoracoscopic lobectomy. In early January 2017, he re-hospitalized due to fever, dizziness and weakness. He was diagnosed with lung adenocarcinoma complicated with pneumonia and septic shock. After antibiotic therapy, patient was referred to physical therapy because of muscle weakness, poor balance control and limited activities of daily living function. The purpose of this case report was to describe the effect of physical therapy for a patient with lung adenocarcinoma complicated with pneumonia and septic shock. Methods: During hospitalization, the patient received bedside physical therapy once a day for 30 minutes. Bedside treatment includes training for muscle strength, standing balance, ambulation, functional activity, recommendations and health education for the assistive technology, and self-directed exercise program. Barthel Index (BI), Berg Balance Scale (BBS), 5-meter walk test (5MWT), and 6-minute walk test (6MWT) were measured before intervention and at 15-day post-intervention. Results: The patient improved scores on BI from 0/100 to 60/100 and BBS from 4/56 to 28/56. The patient was unable to walk independently and bedridden before intervention, but he walked by walker with speed of 0.5 m/s and walking distance for 6MWT is 100 m after intervention. Conclusion: This case report demonstrated that physical therapy can improve the activities of daily living function, balance and walking ability for a patient with lung adenocarcinoma complicated with pneumonia and septic shock. Clinical Relevance: This report demonstrates the positive effect of physical therapy for lung adenocarcinoma complicated with pneumonia and septic shock.