本研究目的欲探討低氧加運動對肥胖基因鼠(obese Zucker rat)血清瘦體素、血糖吸收能力及肥胖程度的影響。胖、瘦各32隻體重約100克的Zucker雄鼠,分別給予兩組老鼠8週低氧、運動或低氧加運動的介入,測量老鼠攝食量、體重、脂肪量、血清瘦體素及血糖吸收能力。本研究結果顯示:低氧加運動能有效將Zucker胖鼠的攝食量降低至與Zucker瘦鼠相同,運動只有減少Zucker胖鼠的體重,但低氧加運動可以減少Zucker瘦、胖鼠的體重。運動減少胖和Zucker瘦鼠的脂肪量,但低氧加運動對脂肪量的減少沒有加成的效果。運動降低Zucker瘦、胖鼠血清瘦體素濃度,且運動加低氧可以有加成的效果。運動改善Zucker胖鼠血糖的控制能力,低氧加運動對Zucker瘦、胖鼠的血糖吸收能力皆有加成的效果。本研究結論顯示低氧加運動可以更有效的減肥和改善血糖吸收能力,未來可以使用低氧合併運動來改善第二型糖尿病病患的肥胖程度及血糖吸收能力。
Purpose: This study was aimed to examine the interactive effects of hypoxia plus exercise training on obese level, serum leptin and glucose uptake in obese and lean Zucker rats. Methods: Sixty-four Zucker rats both lean (n=32) and obese (n=32) were divided into 8 groups such as, lean control (LC, n=8), lean hypoxia (LH, n=8), lean exercise (LE, n=8), lean hypoxia + exercise (LHE, n=8), obese control (OC, n=8), obese hypoxia (OH, n=8), obese exercise (OE, n=8) and obese hypoxia + exercise (OHE, n=8). In all groups food intake, bodyweight, fat mass, serum leptin and glucose uptake were measured after the treatment. Results: The food intake was higher in obese control group and this was significantly decreased with hypoxia plus exercise treatment which is similar to the LHE group. We observed reduces bodyweight only in obese exercised group, however, hypoxia with exercise resulted in both lean and obese groups. Exercise also reduces the fat mass in both lean and obese groups whereas, no change with interaction of hypoxia plus exercise treatment. Serum leptin levels were significantly decreased with exercise and also with hypoxia plus exercise treatments. Glucose uptake was improved with hypoxia plus exercise treatment in both lean and obese groups. Conclusion: These results indicate that hypoxia with exercise training considered as more effective on reducing fat mass and improving glucose uptake. This data suggest that interactive treatment may be a suitable strategy to control the obese degree and blood glucose level in obese population.