Effect of Lingzhi on Plasma Glucose Concentration

靈芝對糖尿病鼠血糖濃度的影響

陳明德(Ming-Der Chen) ； 宋育民(Yuh-Min Song)

《臺灣農業化學與食品科學》 43卷5期 (2005/10) Pp. 376-379

https://doi.org/10.6578/TJACFS.2005.047

摘要

動物試驗發現靈芝(Ganoderma lucidum)具有對抗糖尿病高血糖的效果，然而其臨床療效並不顯著。本試驗在探討靈芝降低糖尿病高血糖的效果是否與靈芝的服用處理時間有關。鼴鼠分別在注射鏈佐黴素（藉以誘發產生糖尿病）的前l週或注射後l週，進行給予2週靈芝處理。試驗結果顯示在注射鏈佐黴素前就接受靈芝處理的鼴鼠會有明顯較低的血糖濃度，與較高的血胰島素濃度及抗氧化能力。不過，靈芝對經過鏈佐黴素注射1週後已經出現糖尿病高血糖的鼴鼠則無明顯改善效果。本試驗結果指出靈芝可能藉由其抗氧化作用而有對抗鏈佐黴素所造成的胰臟傷害。

關鍵字

靈芝 ； 糖尿病 ； 高血糖 ； 鏈佐黴素

並列摘要

”Ganoderma lucidum”, well-known as lingzhi, is claimed to have an anti-diabetic function. However, its clinical efficacy is still illusive. This study was to investigate whether the efficacy of lingzhi on reducing diabetic hyperglycemia is related to its time of administration. Streptozotocin (STZ)-induced diabetic mice were given a 2-week lingzhi supplementation either from 1 week prior to or 1 week after STZ injection. Mice received lingzhi treatment prior to STZ injection had significantly reduced fasting blood sugar, as well as increased plasma values of insulin and total antioxidant capacity. There was no significant change in glucose level in those STZ-treated mice which had lingzhi administration after established hyperglycemia. The results of this study suggest that lingzhi may act as an antioxidant to protect against STZ-induced pancreatic damage.

並列關鍵字

Ganoderma lucidum ； Lingzhi ； Diabetes mellitus ； Hyperglycemia ； Streptozotocin