- 期刊
Intrapulmonary Thrombolytic Therapy in a Child with Acute Pulmonary Embolism due to Primary Antiphospholipid Syndrome
經肺動脈血栓溶解術治療—因原發性抗磷脂症候群所引起之孩童急性栓塞
摘要
肺栓塞於孩童爲罕見，但具高致命性且須緊急處理的疾病。抗凝劑爲傳統標准的肺栓塞治療方式，然而最近於成人的研究報告顯示：經肺動脈血栓溶解術可使血栓更快，更完全地溶解，身體較快恢複，因而降低慢性肺部血管病變且較少全身性副作用。此種治療方式通常建議使用在大量血檢造成生命跡象不穩定或有右心室衰竭時，甚少有人報告於小孩使用的經驗。在這篇文章，我們報告一個十歲的女孩，她因原發性抗磷脂症候群而引起廣泛多發性肺栓塞。經過heparin持續靜脈注射三天後，症狀持續存在且肺部血管攝影顯示血栓並未溶解。而改以streptokinase經肺動脈注射十二小時後，症狀明顯改善且肺部血管攝影顯示血栓已經溶解。
並列摘要
Pulmonary embolism (PE) is a rare but life-threatening condition, which needs emergent treatment in children. Though anticoagulation is the standard treatment for PE, recent studies revealed intrapulmonary thrombolytic therapy may produce more rapid clot lysis and less systemic complications in adult patients. We reported a 10-year-old girl who had diffused multiple pulmonary emboli due to primary antiphospholipid syndrome. The thrombi persisted in spite of intravenous heparin infusion for 3 days, which resolved quickly after intrapulmonary streptokinase infusion for 12 hours.