Insulin Resistance in Obese Adolescents

肥胖青少年的胰島素抗性

李欣蓉(Hsing-Jung Li) ； 黃琪鈺(Chi-Yu Huang) ； 李宏昌(Hung-Chang Lee) ； 陳銘仁(Ming-Ren Chen) ； 羅福松(Fu-Sung Lo) ； 林昭旭(Chao-Hsu Lin) ； 王安美(An-Mei Wang) ； 施並富(Bing-Fu Shih) ； 李燕晉(Yann-Jinn Lee)

《Acta Paediatrica Taiwanica》 46卷2期 (2005/04) Pp. 61-66

https://doi.org/10.7097/APT.200504.0061

並列摘要

The prevalence of obesity in adolescents is increasing rapidly. Obesity is associated with insulin resistance, which increases the risk for type 2 diabetes. We investigated insulin resistance in obese adolescents and its relationship to acanthosis nigricans. Height, weight and body mass index (BMI) were measured and each was expressed as a standard deviation score (SDS) based on national growth standards. Insulin resistance was estimated by using the homeostasis model assessment (HOMA-IR) score, calculated as fasting insulin (μU/mL)×fasting glucose (mmol/L)/22.5. Obese adolescents had significantly greater weight-SDS, BMI-SDS, fasting insulin levels, and HOMA-IR than did controls with normal weight. Acanthosis nigricans was present in 58.4% of obese adolescents. Fasting insulin levels and BMI-SDS were positively correlated with the degree of acanthosis nigricans (r=0.383, P＜0.0001 and r=0.164, P＜0.05, respectively). On multiple regression analysis, HOMA-IR and BMI-SDS explained 16.8% of the degree of acanthosis nigricans (P＜0.0001). Acanthosis nigricans thus may be a marker of insulin resistance and should be carefully looked for in obese adolescents.

並列關鍵字

obesity ； adolescents ； insulin resistance ； acanthosis nigricans