病例報告：豬皮膚炎腎病症候群

Case Report: Porcine Dermatitis and Nephropathy Syndrome in Pig

林正忠(Cheng-Chung Lin) ； 李維誠(Wei-Cheng Lee) ； 黃千衿(Chien-Jin Huang) ； 陳冠豪(Gung-Haw Chen) ； 劉正義(Cheng-I Liu) ； 簡茂盛(Maw-Sheng Chien)

《臺灣獸醫學雜誌》 30卷1期 (2004/03) Pp. 33-38

https://doi.org/10.7009/TVJ.200403.0033

摘要

中部某一貫式豬場，飼養總頭數約10,000頭，於2002年五，六月間在三月齡生長豬群發現數頭豬隻在後肢與臀部皮膚，有多發密集之紅紫色皮下出血斑，部分區域可見痂皮；發病率約1%，但未見死亡疫情。剖檢見皮膚呈多發出血；腎臟表面可見散發白點及皮質部針狀出血當；全身淋巴結嚴重充血、腫脹。組織病理學檢查於皮膚可見許多明顯之壞死性血管炎；腎臟可見絲球體性腎炎及間質性腎炎；淋巴組織見淋巴球流失及大量多核巨細胞。PCR檢測及原位雜合試驗，可在淋巴組織與部分病變處呈豬第二型環狀病毒（PCV2）陽性反應，最終診斷為豬皮膚炎腎病症候群。本病病因與致病機轉疑與PCV2感染反過敏反應有關；本病例之病理學與分子生物學結果可提供其他PCV感染之診斷參考。

關鍵字

PDNS ； 豬皮膚炎腎病症候群

並列摘要

In May 2002, a pig farm raised about 10000 pigs in the central Taiwan. The owner complained about some 3 month-old growing pigs revealed irregular macules in the skin, the morbidity was 1%, but none of them was dead. The pathological findings as following: Remarkable red-to-purple, irregular, variable sized macules and papules in the skin, mainly located in hind limbs and perineal area, which tend to coalesce. Necrotizing vasculitis with fibrinoid necrosis of the blood vessel wall of the skin was noted. The kidneys were enlarged and mottled with tiny white/red spots, and acute vasculitis, fibrinonecrotic glomerulonephrtis were the characteristic microscopic lesions. Enlarged lymph nodes revealed lymphocyte depletion and edematous fluid filled, typical multinucleate giant cells were noticed also (granulomatous lymphadenopathy). All of the lymphoid organs revealed positive PCV2 PCR reaction. Positive signals were found when using in situ hybridization to detect of PCV2 nucleic acid in the lymph nodes and giant cells. The final diagnosis of the pigs was porcine dermatitis and nephropathy syndrome (PDNS). The etiology and pathogenesis of PONS were still unknown, but the lesions suggested that a type III hypersensitivity a possible pathogenic mechanism for the disease.

並列關鍵字

pig ； Porcine Dermatitis and Nephropathy Syndrome ； PDNS