The Valuation of Blood and Tissue Enzymes for Clinical Diagnosis in New Zealand White and Rex Rabbits

紐西蘭與雷克斯兔血液及組織器官之酵素活性分析與臨床診斷評估

余章游(Chang-You Yu) ； 吳錫勳(His-Hsun Wu) ； 葉瑞涵(Ruei-Han Yeh) ； 陳綵慈(Tsai-Tzu Chen) ； 陳國隆(Kuo-Lung Chen)

《臺灣獸醫學雜誌》 35卷1期 (2009/03) Pp. 1-8

https://doi.org/10.7009/TVJ.200903.0001

摘要

The purpose of this study is to standardize blood and tissue enzyme activities in New Zealand White (NZW) and Rex (REX) rabbits in order to contribute to clinical diagnosis. Fifteen healthy male NZW and REX rabbits at 8-week-old, respectively, were used to measure enzyme activities including alkaline phosphatase (ALP), γ-glutamyltransferase (GGT), alanine aminotransferase (ALT), aspartate aminotransferase (AST), lactate dehydrogenase (LDH), creatine kinase (OK) and a-amylase (AMYL) in blood, liver, brain, heart, pancreas, spleen, kidney and thigh muscle. The blood from the REX had higher ALT and lower LDH and ALP activities than those from the NZW (P＜0.05). In tissue enzymes, the liver ALP spleen AMYL and kidney ALT activities were higher in the REX than those in the NZW (P＜0.05). Regarding to the tissue distributions of the enzymes, ALP (56-60%) and GGT (74-75%) were mainly present in kidney, and those should be an indicator of kidney damage. 86-93% of AMYL was found in pancreas, a specific enzyme should be used to aid diagnosis of pancreatic abnormalities.

關鍵字

血液化學 ； 臨床酵素 ； 紐西蘭白兔 ； 雷克斯兔 ； 組織酵素

並列摘要

The purpose of this study is to standardize blood and tissue enzyme activities in New Zealand White (NZW) and Rex (REX) rabbits in order to contribute to clinical diagnosis. Fifteen healthy male NZW and REX rabbits at 8-week-old, respectively, were used to measure enzyme activities including alkaline phosphatase (ALP), γ-glutamyltransferase (GGT), alanine aminotransferase (ALT), aspartate aminotransferase (AST), lactate dehydrogenase (LDH), creatine kinase (OK) and a-amylase (AMYL) in blood, liver, brain, heart, pancreas, spleen, kidney and thigh muscle. The blood from the REX had higher ALT and lower LDH and ALP activities than those from the NZW (P＜0.05). In tissue enzymes, the liver ALP spleen AMYL and kidney ALT activities were higher in the REX than those in the NZW (P＜0.05). Regarding to the tissue distributions of the enzymes, ALP (56-60%) and GGT (74-75%) were mainly present in kidney, and those should be an indicator of kidney damage. 86-93% of AMYL was found in pancreas, a specific enzyme should be used to aid diagnosis of pancreatic abnormalities.

並列關鍵字

blood chemistry ； clinical enzyme ； New Zealand White rabbit ； Rex rabbit ； tissue enzyme