手術治療貓疫苗相關肉瘤之回溯性研究：57例(2002-2009)

Retrospective Survey of Surgical Excision of Feline Vaccine-Associated Sarcoma: 57 Cases (2002-2009)

周贊慧(Tzann-Huey Chou) ； 邱慧英(Huey-Ying Chiou) ； 鄭穹翔(Chiung-Hsiang Cheng) ； 葉力森(Lih-Sen Yeh)

《臺灣獸醫學雜誌》 37卷1期 (2011/03) Pp. 53-62

https://doi.org/10.7009/TVJ.201103.0053

摘要

貓疫苗相關肉瘤(vaccine-associated sarcoma; VAS)，為一惡性程度高且難以治癒的腫瘤。本研究共收集自2002年至2009年，57例診斷為貓疫苗注射相關肉瘤之病例進行分析。於手術病例中，腫瘤最大直徑中位數為5公分。中位數無病時間為120日，中位數存活時間為210日，且至研究終了已有49%之病例已死於該腫瘤相關原因。腫瘤切除後傷口癒合不良為手術之主要併發症，但不必然與預後有關；4例病患於末期發生後軀癱瘓之現象，其中2例並分別以電腦斷層及屍解證實與腫瘤相關，此為首篇提出貓疫苗相關肉瘤可能導致癱瘓的較大型研究。整體而言，台灣地區對於貓疫苗相關肉瘤之認知仍然不足，雖然其發生率不高，但因為一旦發生即難以治癒，因此在替貓注射疫苗（或其他藥物）前均須加以仔細評估，並且在出現疑似病灶時，立即進行正確之醫療處置。

關鍵字

貓 ； 疫苗相關內瘤 ； 台灣地區

並列摘要

Feline vaccine-associated sarcoma (VAS) is a tumor with high malignancy and is hard to be cured. Medical records of 57 cats with the histologic diagnosis of VAS between 2002 and 2009 in Taiwan were reviewed. In the surgery cases, the median size of tumors at the greatest diameter is 5.0 cm. The median disease free interval and the median survival time are 120 and 210 days, respectively. At the end of the study, 28 of 57 (49%) cats were dead because of the tumor related reasons. The main complication after surgical excision is healing disorder, however which do not inevitably lead to poorer prognosis. Hindquarter paralysis developed in 4 cats, 2 were confirmed by CT scan and post-mortem examination to be related with tumor invasion. This is the first retrospective study to bring up the possibility that VAS may lead to paralysis. In addition, clients and veterinarians in Taiwan substantially lack the awareness of VAS. Although the incidence of VAS is relatively low, complete evaluation is strongly advised before doing any injection or vaccination due to the aggressiveness and difficulty of management of this tumor. And the veterinarians should do accurate diagnosis immediate and aggressive management to vaccine-associated sarcomas.

並列關鍵字

cat ； Taiwan ； vaccine-associated sarcoma