Tuberculosis is still one of the most frightened contagious in the world. It threatens the lives of human beings. The tuberculosis patients are facing extreme sufferings both in physiology and psychology. This study aims to understand the relevant nursing problems that caused in hospitalization due to illness limitation and isolation treatment. Related information was collected by physical assessment, interview, observation, etc. Because of the illness the patient would have fever, dystrophy and other health problems. And due to the isolation treatment the patient had anxiety reaction and felt social contact segregation. Individual and continuing nursing was applied by active concern and effective communication. Relevant hygienic knowledge was also provided in order to help patients solve the health problems easily. The study can be taken as reference for nursing staffs taking care of the tuberculosis patients.