Metformin對血糖及骨骼肌肝醣儲存之影響

Oral Metformin Effects Blood Glucose and Stored Glycogen on Skeletal Muscle after Exercise

林勁宏(Ching-Hung Lin) ； 游文杉(Wen-Shan Yu) ； 林志遠(Chi-Yuan Lin) ； 李文志(Wen-Chih Lee)

《輔仁大學體育學刊》 5期 (2006/05) Pp. 133-143

https://doi.org/10.29697/JPE.200605.0012

摘要

Exercise and metformin have both been found to enhance insulin sensitivity in vivo. Therefore, the purpose of the study was to determine the effect of post-exercise metformin administration on muscle glycogen storage in vivo condition. 30 Sprague-Dawley rats were evenly divided into 3 groups: control (C), exercise (E), and exercise-metformin (EM). Metformin was orally provided 500 g daily for 5 days. Exercise protocol consists of 3 h X 2 swimming. Under fasted condition, rats were provided 1 g (50% V/W) glucose. Blood glucose was measured 30 min after oral glucose intubation. 5 h after exercise, muscle glycogen levels in red and white portion of the quadriceps muscle were measured. We found blood glucose concentration in EM group was significantly lower than the rest of groups C: 106±4.52 E: 92.7±3.95 EM: 77.4±4.79 mg/dl, p＜.05). Glycogen supercompensation was only observed in the exercised muscle without metformin treatment. Furthermore, metformin did not enhance muscle glycogen storage. In soleus, both exercise and metformin did not cause glycogen supercompensation. In conclusion, post-exercise metformin treatment did not enhance muscle glycogen storage.

關鍵字

Metformin ； 肝醣超載 ； 肌纖維 ； 葡萄糖吸收能力

並列摘要

Exercise and metformin have both been found to enhance insulin sensitivity in vivo. Therefore, the purpose of the study was to determine the effect of post-exercise metformin administration on muscle glycogen storage in vivo condition. 30 Sprague-Dawley rats were evenly divided into 3 groups: control (C), exercise (E), and exercise-metformin (EM). Metformin was orally provided 500 g daily for 5 days. Exercise protocol consists of 3 h X 2 swimming. Under fasted condition, rats were provided 1 g (50% V/W) glucose. Blood glucose was measured 30 min after oral glucose intubation. 5 h after exercise, muscle glycogen levels in red and white portion of the quadriceps muscle were measured. We found blood glucose concentration in EM group was significantly lower than the rest of groups C: 106±4.52 E: 92.7±3.95 EM: 77.4±4.79 mg/dl, p＜.05). Glycogen supercompensation was only observed in the exercised muscle without metformin treatment. Furthermore, metformin did not enhance muscle glycogen storage. In soleus, both exercise and metformin did not cause glycogen supercompensation. In conclusion, post-exercise metformin treatment did not enhance muscle glycogen storage.

並列關鍵字

metformin ； glycogen supercompensation ； muscle fiber ； glucose uptake

參考文獻

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