National Data on Colorectal Cancer Trends: A Population-Based Study in Taiwan

大腸直腸癌趨勢的國家資料：台灣的人口研究

周家麟(Chia-Lin Chou) ； 翁世峰(Shih-Feng Weng) ； 鄭立勤(Li-Chin Cheng) ； 田宇峯(Yu-Feng Tian)

《中華民國大腸直腸外科醫學會雜誌》 24卷1期 (2013/03) Pp. 1-8

https://doi.org/10.6312/SCRSTW.2013.24(1).10111

摘要

目的　在不同年齡層發病的大腸直腸癌預後，目前仍無定論。此篇研究是分析台灣的癌症登記資料來分析，不同年齡層大腸直腸癌的預後差異。方法　本研究收集了自1998年到2005年，台灣大腸直腸癌的癌症登記資料。於1998至2005年間，共有65113位診斷為大腸直腸癌，其中62060位病患有組織學確定診斷為大腸直腸腺癌、黏液性癌或戒指型細胞癌，收錄在本研究中。將這些病人的病理及存活的資料予以分析。結果　從1998年到2005年間，小於40歲的大腸直腸癌病患比率，由6.8%降到4.6%。在2000年之前，大腸直腸癌主要分布在51~60歲和61~70歲；2000年之後，61~70歲和71~80歲躍昇為主要族群。小於40歲的大腸直腸癌病患相較於其他年齡層的病患（41~50歲、51~60歲、61~70歲），有較高的黏液性癌或戒指型細胞癌的發生率及較差的1年、3年、5年總體存活率和癌症存活率。結論　根據國家癌症登記的資料，目前在台灣的大腸直腸癌病患並沒有年輕化的趨勢。小於40歲的大腸直腸癌病患有較差的組織學型態，且相較於其他年齡層的病患（41~50歲、51~60歲、61~70歲）有較差的預後。

關鍵字

結腸直腸癌 ； 年紀 ； 預後

並列摘要

Purpose. The prognosis of patients having different ages at the onset of colorectal cancer (CRC) is controversial. The aim of this study was to complete a comprehensive analysis of the relationship between age differences and CRC survival using population registries from Taiwan.Methods. For patients diagnosed with CRC between 1998 and 2005, we analyzed survival data derived from the Taiwan Cancer Registry database. During this time period, 65,113 patients were registered, and 62,060 patients, presenting definite histological evidence of adenocarcinoma, mucinous adenocarcinoma, or signet-ring cell carcinoma of the colon and rectum, were enrolled into this cohort study. Age differences in pathological characteristics and prognosis were analyzed.Results. From 1998 to 2005, the proportion of patients diagnosed at a younger age (≤ 40-years-of-age group) decreased from 6.8% to 4.6%. Until 2000, most individuals in the CRC patient group were in the sixth and seventh decade. Individuals in the seventh and eighth decade replaced this group after 2000, and became the majority. Younger patients (≤40-years-of-age group) had a higher incidence of mucinous adenocarcinoma (p ＜ 0.001) and signet-ring cell carcinoma (p ＜ 0.001), and poorer 1-year, 3-year, 5-year overall survival (p ＜ 0.001) and cancer-specific survival (p ＜ 0.001) than elderly patients (the 41-50, 51-60, and 61-70 year groups).Conclusions. National data on colorectal cancer trends clearly indicate that currently, in Taiwan, colorectal cancer rates are not showing an increase in younger generations. More aggressive histopathologic characteristics and poorer overall and cancer-specific survival were noted in younger, as compared to older CRC patients.

並列關鍵字

Colorectal cancer ； Age ； Prognosis