Risk Factors for Stroke

腦中風的危險因子

陳年(Nien Chen) ； 蕭正光(Zhen G. Shaw) ； 曹汶龍(Wen L. Cao) ； 李燕鳴(Yen M. Li) ； 鄭南成(Nan C. Zhen) ； 張君悌(Jun T. Chang) ； 陳秋美(Qiu M. Chen)

《明新學報》 33期 (2007/07) Pp. 47-53

https://doi.org/10.29688/MHJ.200707.0003

摘要

腦中風為全球十大死因之一，也是中老年人殘障的主要原因。台灣地區每十萬人中，就有六十人死於腦中風疾病，僅次於惡性腫瘤。腦中風的病因尚不完全清楚，基本上是先天遺傳和後天因素的交互影響所致。本研究的目的是檢測腦中風危險因子與不同年齡層病患的相關性。根據所獲資料之研究與分析，其結果除了確認患高血壓的人易患中風外，本研究數據顯示：1.高密度脂蛋白與腦中風似乎有負相關性；2.女性在四十歲至六十歲之間，發生腦中風的危險性與身高亦似為負相關；同時尿酸偏高也可能為腦中風的因子之一。此研究所得之資訊將有助於腦中風病因的探索與確定。明瞭腦中風發病的機制並掌控其發病的各項危險因子，當可收到早作防治此種病症之效益。

關鍵字

腦中風 ； 危險因子 ； 身高 ； 高密度脂蛋白

並列摘要

Cerebrovascular Disease (CVD) or Stroke (Cerebrovascular Accident, CVA, or Apoplexy) has been one of the leading causes of death worldwide. It is also the second most common cause of neurologic disability after Alzheimer's disease and remains the major reason of institutional placement for loss of independence among adults. The etiology and pathophysiology of CVD are complex and multifactorial. The aim of the present study is to investigate the interrelationship between some candidate risk factors and stroke incidences among different age groups. The results demonstrated and/or confirmed the associations between hypertension and stroke incidence. More significantly, the data suggested that body height, especially in females, was inversely associated with stroke incidence for individuals from age 40 to 60. High Density Lipoprotein (HDL) appeared to play a protective role in stroke. In addition, the study revealed a circumstantial association between uric acid and stroke incidence. New findings obtained regarding the risk factors for stroke incidence could facilitate the identification of individuals at increased risk of the disease. To comprehend the risk factor basis of stroke would have immediate clinical and public health benefits by guiding novel therapeutic approaches, aiding new drug discovery, and suggesting an appropriate life style for those at risk.

並列關鍵字

stroke ； risk factors ； height & HDL

參考文獻

Carolei A,Sacco S,DeSantis F,Marini C.(2002).Epidemiology of stroke.Clin & Experimental Hypertension.24,479-483.

Truelsen T,Bonita R(2003).Advances in ischemic stroke epidemiology.Advances in Neurology.92,1-12.

Anderson CS,Carter KN,Hackett ML,Feigin V,Barber PA,BroadJB, Bonita R(2005).Trends in stroke incidence in Auckland, New Zealand, During 1981 to 2003.Stroke.36,2087-2093.

Lee TH,Hsu WC,Chen CJ(2002).Etiologic study of young ischemic stroke in Taiwan.Stroke.33,1950-1955.

Liu HM,Tu YK,Yip PK(1996).Evaluation of intracranial and extracranial carotid steno-occlusive diseases in Taiwan Chinese patient with MR angiography: preliminary experience.Stroke.27,650-653.