宜蘭地區蛋白尿盛行率與相關因子之探討

Prevalence of Proteinuria and Associated Factors of the Middle-Aged and Elderly Taiwanese Population in I-Lan County

羅于韵(Yu-Yunn Lo) ； 陳亮恭(Liang-Kung Chen) ； 陳振文(Tzen-Wen Chen) ； 黃信彰(Shinn-Jang Hwang) ； 陳稚均(Zhi-Jun Chen)

《臺灣家庭醫學研究》 3卷1期 (2005/01) Pp. 6-14

https://doi.org/10.29475/TFMR.200501.0002

摘要

Proteinuria is a common marker for renal diseases; and has been associated with cardiovascular diseases. Protienuria may be attributed to various etiologies, including hypertension, diabetes mellitus, renal insufficiency, and advancing age. The purpose of this study is to explore the prevalence of proteinuria and to analyze the associated factors in the middle-aged and elderly in I-Lan county.
A community-based study for metabolic disorders and related factors among residents aged over 40 in I-Lan County were conducted in 2000. History taking, anthropometric measurements, and blood samplings were performed in detail by experienced research staff. Insulin resistance was measured and expressed by homeostasis model assessment (HOMA-IR). The relationship between proteinuria and a number of factors including age, sex, insulin resistance, chronic kidney disease (CKD), obesity, hypertension and diabetes mellitus (DM), were carefully examined for clarification.
A total of 1,062 subjects (473 males and 589 females, mean age=64.4±11.3 years) participated the study, and insulin resistance was evaluated among 734 subjects (HOMA-IR expressed by mean standard error of mean=1.19±0.09). In total, 13.3% of all subjects had overt proteinuria, and was significantly related to DM, hypertension, insulin resistance, and had higher rate of CKD (all p＜0.001). Further analysis disclosed that subjects with comorbid hypertension and DM (31.6%) were the most risky for proteinuria. Among subjects with porteinuria, they were significantly older (68.4±10.8 vs. 63.8±11.2 years, p＜0.001), had higher HOMA-IR (3.00±0.37 vs. 1.48±0.08, p＜0.001), and lower glomerular filtration rate (58.41±17.79 vs. 68.41±13.74 mL/min/1.73m^2, p＜0.001). By using binary logistic regression, we found that hypertension, insulin resistance, and CKD were all significant predictive factors for proteinuria. The prevalence of overt proteinuria among the middle-aged and elderly population in ILan county was 13.3%. Hypertension, CKD, and insulin resistance can independently predict the presence of proteinuria.

並列摘要

Proteinuria is a common marker for renal diseases; and has been associated with cardiovascular diseases. Protienuria may be attributed to various etiologies, including hypertension, diabetes mellitus, renal insufficiency, and advancing age. The purpose of this study is to explore the prevalence of proteinuria and to analyze the associated factors in the middle-aged and elderly in I-Lan county.
A community-based study for metabolic disorders and related factors among residents aged over 40 in I-Lan County were conducted in 2000. History taking, anthropometric measurements, and blood samplings were performed in detail by experienced research staff. Insulin resistance was measured and expressed by homeostasis model assessment (HOMA-IR). The relationship between proteinuria and a number of factors including age, sex, insulin resistance, chronic kidney disease (CKD), obesity, hypertension and diabetes mellitus (DM), were carefully examined for clarification.
A total of 1,062 subjects (473 males and 589 females, mean age=64.4±11.3 years) participated the study, and insulin resistance was evaluated among 734 subjects (HOMA-IR expressed by mean standard error of mean=1.19±0.09). In total, 13.3% of all subjects had overt proteinuria, and was significantly related to DM, hypertension, insulin resistance, and had higher rate of CKD (all p＜0.001). Further analysis disclosed that subjects with comorbid hypertension and DM (31.6%) were the most risky for proteinuria. Among subjects with porteinuria, they were significantly older (68.4±10.8 vs. 63.8±11.2 years, p＜0.001), had higher HOMA-IR (3.00±0.37 vs. 1.48±0.08, p＜0.001), and lower glomerular filtration rate (58.41±17.79 vs. 68.41±13.74 mL/min/1.73m^2, p＜0.001). By using binary logistic regression, we found that hypertension, insulin resistance, and CKD were all significant predictive factors for proteinuria. The prevalence of overt proteinuria among the middle-aged and elderly population in ILan county was 13.3%. Hypertension, CKD, and insulin resistance can independently predict the presence of proteinuria.

並列關鍵字

chronic kidney disease ； insulin resistance ； metabolic syndrome ； proteinuria