Appendicitis is the most common cause of acute surgical abdomen in children and young adults. Appendicitis is inflammation of the appendix caused by luminal obstruction, mostly by fecaliths. A missed or delayed diagnosis can lead to appendix rupture and a resultant increase in mortality. Because of anatomical variability and atypical clinical presentations, making a correct diagnosis is still a challenge. Diagnosing appendicitis mostly depends on reviewing the clinical history and a physical examination. An imaging study can decrease the negative appendectomy rate. Although antibiotics alone can be used to treat appendicitis without fecalith obstruction, early surgical treatment is still recommended. Operative procedures include an open appendectomy and laparoscopic appendectomy. Both have advantages and disadvantages. The use of perioperative antibiotics can decrease the incidence of wound infection and intra-abdominal abscess.