- 期刊
Polymorphisms of Human Platelet Antigens and Coagulation Factor V Leiden Are not Risk Factors for Stroke in Taiwanese
人類血小板抗原之基因多型性及第五凝血因子Leiden 在臺灣華人缺血性腦中風之危險因子
摘要
人類血小板抗原之基因多型性曾經被認為是缺血性腦中風之危險因子，第五凝血因子之Leiden變異會導致第五凝血因子不被蛋白質C活化，也被認為是缺血性腦中風或深部靜栓塞之危險因子。本研究即針對所有人類血小板抗原之基因多型性及第五凝血因子Leiden變異，於67位缺血性腦中風病人及149位一般老人族群研究其基因多型性之分布。吾人發現人類血小板抗原之基因多型性腦中風之危險因子，而且第五凝血因子之Leiden變異應不存在於臺灣華人。
並列摘要
Objective: Polymorphisms of human platelet antigens (HPA) have been considered to be independent risk factors for myocardial infarction and ischemic stroke. In addition, in the coagulation factor V gene (factor V Leiden), which results in activated protein C resistance, is also associated with increased risk of deep vein thrombosis or ischemic stroke. This study investigated the association polymorphism in HPA and factor V Leiden and the development of vascular diseases in Taiwanese ischemic stroke patients. Methods: A total of 67 patients with ischemic stroke and 149 healthy controls were recruited for participation in this study. The genetic polymorphisms of HPA and factor V Leiden were determined by polymerase chain reaction-restriction fragment length polymorphism. Results: We found difference in polymophisms of HPA between patients with ischemic stroke and controls. No factor V Leiden was found in patients or controls. These suggest that there is no V Leiden in Taiwanese population. Conclusions: We conclude that polymorphisms of HPAs and factor V Leiden are not the genetic risk factor ischemic stroke among Taiwanese.