腸病毒71型感染引起手足口症及疱疹性咽峽炎之流行病學研究

Epidemiology of Hand-Foot-Mouth Disease and Herpangina Caused by Enterovirus 71

鄭晏宗(Yan-Tzong Cheng) ； 陳國東(Kow-Tong Chen) ； 張筱玲(Hsiao-Ling Chang) ； 陳守堅(Shou-Chien Chen)

《北市醫學雜誌》 4卷4期 (2007/04) Pp. 278-285

https://doi.org/10.6200/TCMJ.2007.4.4.03

摘要

手足口症/疱疹性咽峽炎是常見且症狀輕微的孩童疾病。它的臨床特徵是在口，手足會出現水泡甚至潰瘍性水泡。最常見的腸病毒感染是克沙奇A16及腸病毒71型引起。臺灣地區在1998年發生腸病毒71型感染引起的手足口症／咽峽炎大流行，造成405位重症及78人死亡的嚴重疫情。它造成的併發症主要是腦炎，肺水腫或出血，甚至死亡。目前尚不清楚其造成如此重大併發症的原因。本研究是要回顧分析我國疾病管制局腸病毒71型通報資料及國內外相關文獻包括病因學，臨床表徵，診斷，治療等，以提供有關單位做為防治決策參考。

關鍵字

腸病毒71型 ； 基因型分析 ； 腦炎 ； 肺水腫或出血

並列摘要

Hand-foot-mouth disease and herpangina (HFMD/HA) are typical benign and common selflimiting child diseases, characterized by rapidly ulcerating vesicles in the mouth and lesions, usually vesicles, on the hands and feet. HFMD/HA is caused by a few serotypes of enterovirus, most frequently coxsackie virus A16 (CAV A16) and human enterovirus 71 (HEV 71). In 1998, there was a large outbreak of HFMD/HA caused by HEV 71 in Taiwan resulting in 405 severe cases and 78 deaths, which were associated with complications of encephalitis, pulmonary edema/hemorrhage, death. Until now, the reason for the occurrence of this outbreak was unclear. The purpose of this study was to review the updated of HFMD/HA statistics available from the Centers for disease Control, Taiwan (Taiwan CDC) and knowledge of HFMD/HA caused by HEV 71, including etiology, clinical manifestation, diagnosis and treatment, and draw attention to prevention and intervention effort.

並列關鍵字

enterovirus 71 ； genetic analysis ； encephalitis ； pulmonary edema/hemorrhage