Correlation between Eosinophil Cationic Protein and Nasal Polyps in Children

嗜伊紅白血球陽離子蛋白與兒童鼻息肉之相關性

楊鈞智(Chin-Chih Yang) ； 陳亞健(Ya-Jian Cheng) ； 黃弘孟(Hung-Meng Huang)

《北市醫學雜誌》 5卷3期 (2008/06) Pp. 335-341

https://doi.org/10.6200/TCMJ.2008.5.3.05

摘要

Objectives: To evaluate the role of eosinophil cationic protein (ECP) in the formation of nasal polyposis and the correlation between serum ECP, tissue ECP, and the development of nasal polyps. Methods: From January 2003 to December 2006, 80 children suffered from chronic rhinosinusitis were enrolled in the study. Among them, 40 children had nasal polyps. Nasal tissues were obtained from nasal polyps and sinus tissues in children receiving endoscopic sinus surgery. The nasal tissue was grounded into powder. The powder was then dissolved in phosphate buffer saline. The eosinophil cationic protein was detected with an ECP fluroimmunoassay kit and the final eosinophil cationic protein content was calculated per gram nasal tissue. The serum ECP value was checked simultaneously. Forty children had partial inferior turbinectomy were used as controls. Results: The ECP content in nasal polyps (607.59±928.70 ng/g) was higher than that in the sinus tissue (233.70±349.59) and hypertrophic inferior turbinate (74.49±115.58 ng/g). It showed significant difference by statistics (p＜0.05, for both). The ECP content in sinus tissue was also significantly higher than that in the inferior turbinate group (p＜0.05). Nonetheless, the serum ECP in the nasal polyps group was not significantly different from that in the sinus tissue group or the control group (p＞0.05, for both). The tissue ECP content in the nasal polyps correlated with the size of nasal polyps (p＜0.05), nonetheless serum ECP did not. (p＞0.05). Conclusion: A higher ECP content in nasal polyps than in inferior turbinate implies that ECP may play a role in the pathogenesis of nasal polyps. The tissue ECP content correlates well with the size of nasal polyps.

關鍵字

嗜伊紅性白血球陽離子蛋白 ； 鼻息肉 ； 慢性鼻竇炎

並列摘要

Objectives: To evaluate the role of eosinophil cationic protein (ECP) in the formation of nasal polyposis and the correlation between serum ECP, tissue ECP, and the development of nasal polyps. Methods: From January 2003 to December 2006, 80 children suffered from chronic rhinosinusitis were enrolled in the study. Among them, 40 children had nasal polyps. Nasal tissues were obtained from nasal polyps and sinus tissues in children receiving endoscopic sinus surgery. The nasal tissue was grounded into powder. The powder was then dissolved in phosphate buffer saline. The eosinophil cationic protein was detected with an ECP fluroimmunoassay kit and the final eosinophil cationic protein content was calculated per gram nasal tissue. The serum ECP value was checked simultaneously. Forty children had partial inferior turbinectomy were used as controls. Results: The ECP content in nasal polyps (607.59±928.70 ng/g) was higher than that in the sinus tissue (233.70±349.59) and hypertrophic inferior turbinate (74.49±115.58 ng/g). It showed significant difference by statistics (p＜0.05, for both). The ECP content in sinus tissue was also significantly higher than that in the inferior turbinate group (p＜0.05). Nonetheless, the serum ECP in the nasal polyps group was not significantly different from that in the sinus tissue group or the control group (p＞0.05, for both). The tissue ECP content in the nasal polyps correlated with the size of nasal polyps (p＜0.05), nonetheless serum ECP did not. (p＞0.05). Conclusion: A higher ECP content in nasal polyps than in inferior turbinate implies that ECP may play a role in the pathogenesis of nasal polyps. The tissue ECP content correlates well with the size of nasal polyps.

並列關鍵字

eosinophil cationic protein ； nasal polyps ； chronic rhinosinusitis