A patient with terminal Amyotrophic Lateral Sclerosis (ALS) was intubated at emergency room because of dyspnea on June 25, 2008. Then, he needed to utilize mechanical ventilator for respiratory support and was transferred to the intensive care unit. The patient understood the mechanical ventilator could prolong the survival time, but not improve the quality of life and dignity. Finally, patient decided not to perform the tracheotomy. After discussion with palliative shared-care doctor on July 14, he requested for ventilator withdrawal and was transferred to the hospice ward on the next day. The authors provided palliative care for the patient until August 9. The course of hospice care and ventilator withdrawal for this patient would be discussed in legal, ethical and emotional aspects.