注意力缺陷過動症及相關磁振頻譜檢查

ADHD and Its Magnetic Resonance Spectroscopy Examination

陳素秋(Shu-Chiou Chen) ； 臧汝芬(Ruu-Fen Tzang) ； 黃武達(Wu-Dar Huang) ； 楊斐適(Fei-Shish Yang) ； 黃榮貴(Jon-Kway Huang) ； 莊奇容(Chi-Long Juang)

《台灣應用輻射與同位素雜誌》 5卷1期 (2009/03) Pp. 613-622

https://doi.org/10.29832/TJARI.200903.0006

摘要

注意力缺陷過動症是一種在兒童和青少年期最常見的神經行爲異常，主要症狀包括無法集中注意力、無法控制衝動和持續的過動行爲，並造成學童課業上及人際互動上的困擾。本文首先闡明注意力缺陷過動症的致病成因、分類與生理機轉，並說明其臨床常規診斷及治療方式。目前醫學界對過動症成因尚無定論，文獻調查顯示，過動症患者除了多巴胺分泌異常之外，有可能是由於大腦細微功能欠佳所致。這在一般影像學上是無法觀測出來的，因而近來有人利用功能性磁振造影來探討腦中病灶區的位置及變化，也有人利用磁振頻譜來探討腦部新陳代謝物的變化。本文因此也介紹了前人的文獻中有關磁振頻譜檢查對過動症的相關研究與技術的應用，藉以提供國人進行過動症研究時的參考及比較。

關鍵字

注意力缺陷過動症 ； 過動兒 ； 多巴胺 ； 磁振頻譜

並列摘要

Attention-Deficit Hyperactivity Disorder (ADHD) is a neurological behavior abnormality which frequently seen in childhood and adolescence. Main symptoms are including unable to concentrate, cannot control the impulse, and sustained hyperactive behaviors. It also causes problems on learning and interpersonal relationships. In this article, we interpreted the causes of this disease, its subtype and its physiological mechanism, as well as its diagnosis and treatment methods. Currently, there is no final conclusion on the cause of ADHD. However, a lot of investigations indicated that this disorder not only related to abnormal dopamine secretion but also related to improper subtle function of brain. Due to these changes cannot be observed in general imaging methods, functional Magnetic Resonance Imaging (fMRI) has been used to study lesion site and changes in the brain while Magnetic Resonance Spectroscopy (MRS) has been used to investigate changes of brain metabolites. Therefore in this article, we also reviewed the applications of researches and techniques related to ADHD study by MRS method as the reference for future ADHD study.

並列關鍵字

Attention Deficit Hyperactivity Disorder ADHD ； Children with ADHD ； Dopamine ； Magnetic Resonance Spectroscopy MRS