The aim of this study was to investigate the effects of vibration and non-vibration foam roller on vascular and muscular stiffness after an acute bout of high-intensity resistance training. Methods: Ten college students volunteered to participate in this repeated-measures designed study. All participants performed 3 sets × 5 reps at 90% one repetition maximum (1RM) with leg press machine. After exercise, participants used vibration or non-vibration foam roller to massage right quadriceps immediately with a randomized order. Muscle (elastography) and vascular (brachial-ankle pulse wave velocity, ankle-brachial index) stiffness were measured in both legs before and after exercise. Results: Regardless of the types of foam roller, there was no significant difference in muscular stiffness index. For vascular function, ankle-brachial index and brachial systolic blood pressure significantly increased after exercise in both groups; however, there was no group and time difference on vascular parameter changes. Conclusion: We concluded that immediate intervention of foam roller after exercise did not appear to affect muscular and vascular stiffness.