Formocresol was used as the medicament to do traditional pulpotomy treatment until now. However, scholars still suspected that Formocresol might have toxicity and carcinogenicity. It's because the composition of Formocresol contained 19%Formaldehyde and 25%cresol. Even dentists used 1:5 diluted Formocresol solution, people still worried about the toxicity of this material on the body.Laser application in the pediatric dentistry were more common than before, one of these was laser pulpotomy. Dentists tried to use different lasers like CO2 laser, Nd:YAG laser, Er:YAG laser and diode laser to do pulpotomy. They also expected that laser pulpotomy technique could replace the traditional pulpotomy technique. Therefore, in this review article, we would discuss the differences between these laser pulpotomy techniques and compare the differences between laser and Formocresol.