Sinosenecio baojingensis Y. Liu & Q. E. Yang, a new species of Asteraceae from northwestern Hunan, China, is described and illustrated. Its chromosome number (2n=48) is reported here. The new species is similar to S. euosmus and S. denticulatus in having leafy stems and smooth achenes bearing a pappus. It differs from S. euosmus in its much taller stature (75-150 cm vs. 20-75 cm), the ovate-cordate outline of its leaves (vs. ovate to broadly ovate), its denticulate (vs. crenate) margin, and its much larger size (12-20×10-18 cm vs. 2-5×3-6 cm). From S. denticulatus it differs in its sometimes taller stature (75-150 cm vs. 35-140 cm), and ovate-cordate (vs. reniform) leaves, denticulate (vs. dentate) margin, and its larger size (12-20×10-18 cm vs. 4-14×6-17 cm). From both it differs in having undivided (vs. more or less lobed) leaves and basally expanded but never auriculate (vs. auriculate) petioles. A color plate, line drawings, distribution map, light microscope (LM) photomicrographs of floral characters, and a key to aid in the identification of S. baojingensis and its possible relatives are provided.