蒼朮苷(ATR)是存在於許多菊科植物中的二萜醣苷(diterpenoid glycoside)天然物,而這類植物常使用於中藥材或一般食物中。ATR是致命性劇毒性物質,會造成人類及畜養動物之腎小管或是肝細胞肝小葉中心壞死。本研究運用氣相層析質譜(GC/MS)法分析常見藥用菊科植物(蒼朮、白朮及蒼耳)的ATR含量,藉以評估熱液處理後ATR分子的穩定性及含量變化,並以細胞實驗驗證熱液處理對細胞毒性與活性的影響。質譜分析及定量結果顯示酸化及熱液處理可以破壞ATR的化學穩定性,進一步有效地降解其細胞毒性。本研究針對現代中草藥在使用安全上提出合理的解釋與應用熱液處理的方式。
Atractyloside (ATR) is a diterpenoid glycoside and occurs naturally in Asteraceae plants, many of which are used in foods and ethnomedicines. The toxicity of ATR has caused fatal renal proximal tubule necrosis and/or centrilobular hepatic necrosis in man and farm animals. A GC/MS screening method was optimized to detect the presence of ATR in Atractylodes species which are important herbs used in traditional Chinese medicine. The stability and hydrothermal detoxification of ATR in practical processing were also evaluated quantitatively by chromatographic analysis. In addition, the effects of hydrothermal detoxification of ATR from different processing methods on cell viability were performed. The results suggest that degradation of ATR is a way to increase pharmaceutical safety for the Chinese medicinal industries.
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