- 期刊
The Influences of Place Marketing on Tourists' Perceived Benefits and Visiting Intentions: Test the Moderating Effect of Word-of-Mouth
使用區別分析模式來評估運動預處理保護心臟對抗阿黴素對心臟的傷害
摘要
A highly effective antineoplastic agent, Doxorubicin (DOX), is associated with dose-dependent cardiotoxicity. Some evidence indicates that exercise preconditioning can have cardioprotective effects against DOX-induced cardiac dysfunction. PURPOSE: The purpose of this investigation was to evaluate the effects of exercise preconditioning on DOX-induced cardiac dysfunction using discriminant analysis. With this statistical procedure, we used data from previously completed studies to determine group classification and determine which cardiac function variable is the best predictor of cardiac function. METHOD: Male Sprague-Dawley rats (10 week) were randomly assigned to one of three primary groups: sedentary (SED), wheel running (WR) or treadmill (TM). Following 10 weeks of exercise preconditioning, exercise groups received a bolus i.p. injection of 10 mg/kg of DOX (TM+DOX, WR+DOX). At the same time, the SED group received a bolus injection of either 10 mg/kg of DOX (SED+DOX) or an equivalent volume of saline (SED+SAL). Left ventricle function was assessed ex vivo using an isolated working heart model at 5 days, 10 days, or 28 days post injection. A multiple analysis of variance (MANOVA) was used to determine if a significant difference existed between the five cardiac function variables (ESP, DDP, LVDP, dP/dtmax, and dP/dtmin). Stepwise discriminant analysis was performed to determine which cardiac function variable was the best predictor of cardiac function. Descriptive discriminant analysis was used as a linear classification tool to categorize control and experimental groups. RESULTS: A significant difference existed across the 5 cardiac function variables F(12,344.24)=8.73, P＜0.001. Stepwise discriminant analysis revealed LVDP was the most indicative cardiac function variable remaining in the model (R2 =0.39, F=30.34, P＜0.0001). Five days post DOX treatment, 92% of TM+DOX and 70% of WR+DOX were categorized as SED+SAL. Ten days post DOX exposure, 91% of TM+DOX and 86% of WR+DOX were categorized as SED+SAL. Furthermore, 88% of TM+DOX and 93% of WR+DOX 28 days post DOX treatment were categorized as SED+SAL. CONCLUSION: LVDP appears to be the most indicative ex vivo parameter of cardiac function. The cardiac function of the majority of aerobically trained rats treated with DOX was categorized as SED+SAL up to 28 days post DOX treatment.
並列摘要
阿黴素(Doxorubicin, DOX)是目最有效的化療藥之一，但阿黴素的副作用(心毒素)會造成心衰竭甚至死亡。研究發現運動預適應可以減緩阿黴素對心臟的傷害。本研究目的是使用區別分析模式來判別最好的離體(ex vivo)心臟功能的預測變量。以10 週大SD 公大鼠隨機分配到不運動(SED)，自主運動(WR)及強迫運動(TM)等組。在10 週的運動預適應後，運動組注射10 mg/kg 的DOX(TM+DOX, WR+DOX)。同時SED 組也注射10 mg/kg 的DOX(SED+DOX)或等體積的生理食鹽水(SED+SAL)。在化療後第5、10 及28天測試左心室的離體功能。首先使用多變量變異數分析來確認五個心臟功能變量是否存在顯著差異。然後使用逐步區別分析來確定那個心臟功能變量是最佳預測因子。最後使用區別分析法將所有動物分類到對照組或實驗組。結果：五個心臟功能變量是有顯著差異。使用逐步區別分析法發現LVDP 是模型中最具指標性的心臟功能變量。化療5 天後，92%的TM+DOX 和70%的WR+DOX 被歸類為對照組。化療10 天後，91%的TM+DO 和86%的WR+DOX 組被歸類為對照組。化療28 天後，88%的TM+DOX 和93%的WR+DOX 被歸類為對照組。結論：LVDP 是體外心臟功能最具指標的變量。運動後化療的大鼠心臟功能與控制組相同。
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