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Anti-inflammatory and Anti-nociceptive Activity of ＂Mitragyna parvifolia＂
並列摘要
The present study was designed to evaluate both anti-inflammatory and antinociceptive activity of the ethanolic extract of dried leaves of ＂Mitragyna parvifolia＂ (MPEE), using the Carrageenan-induced paw edema method in rats and Tail-flick method in mice, respectively, at various dose levels. The maximum antiinflammatory effect of the extract was found to be at 300 mg/kg in carrageenan test and this effect was equivalent to phenylbutazone (PBZ) (80 mg/kg, orally) (p＜0.05). The extract also demonstrated marked antinociceptive activity at a dose of 300 mg/kg and the effect was comparable to that of standard drug, Ibuprofen (100 mg/kg orally) (p＜0.05). The results of this study have established the anti-inflamm atory activity and antinociceptive activity of leaf extracts of ＂Mitragyna parvifolia＂.
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