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Pathological Lesions in the Lungs of Neonatal Wistar Rats from Dams Administered Ethanol during Gestation
並列摘要
This study was carried out to investigate the effects of ethanol ingestion during pregnancy on the fetal lungs development. Adult Wistar rats were used and grouped into four groups and each group having four females and two males. Group A was the control group received only distilled water, while groups B, C and D received 0.2mL of 20, 25 and 30% ethanol orally respectively daily for seven days during the 4^th to 10^th day of gestation. After delivery, the fetal lungs were removed and fixed in 10% buffered formalin. The neonates' lungs were prepared through histological techniques and stained with Haematoxylin and Eosin and were studied under the light microscope. The result showed alveolar degeneration, bronchiole-capillary thickening, bronchiolar degeneration and extravasations of erythrocyte in the ethanol treated groups while the control was normal. Ethanol ingestion during pregnancy could lead to ethanol-induced lung damage in the fetuses. Hence, alcohol ingestion should be avoided during pregnancy.
延伸閱讀
- 楊玉純、蘇千玲、陳冠豪、陳宗鵠（2011）。Study the Effects of Inhalation of Nano Particles of Titanium Dioxide on the Lung Function in Rats。呼吸治療，10(1)，1-12。https://doi.org/10.6269/JRT.2011.10.1.01
- Wong, S. H. (1989). The gastric effects of ethanol and their modulation by drugs in rats [doctoral dissertation, The University of Hong Kong]. Airiti Library. https://www.airitilibrary.com/Article/Detail?DocID=U0029-1812201200006842
- Lin, M. T., Chai, C. Y., Sun, S. C., & Kau, S. L. (1977). Myocardial Lesions Produced by External Heat or Cold Exposure in Rats. The Chinese Journal of Physiology, 22(3), 115-125. https://www.airitilibrary.com/Article/Detail?DocID=03044920-197712-22-3-115-125-a
- Huang, C. C., Lee, P. P., Lin, C. C., & Lin, C. L. (1967). Experimental Renal Disease in Rats. Acta Paediatrica Sinica, 8(2), 55-67. https://www.airitilibrary.com/Article/Detail?DocID=00016578-196706-8-2-55-67-a
- Murdakai, T., Buraimoh, A. A., & Kwanashie, H. O. (2011). Histological Observations of the Testis of Wistar Rats Following the Oral Administration of Cotecxin (dihyroartemisinin). International Journal of Animal and Veterinary Advances, 3(5), 402-406. https://www.airitilibrary.com/Article/Detail?DocID=20412908-201110-201507240025-201507240025-402-406