Behavioural Effects of Hydro-methanolic Crude Extract of Aerial Part of Indigofera pulchra in Mice

Y. Tanko ； I. Ezekiel ； A.O. Okpanachi ； A.D.T. Goji ； H. Ndebi ； K.Y Musa ； A. Mohammed

《Current Research Journal of Biological Sciences》 1卷3期 (2009/10) Pp. 89-93

並列摘要

Indigofera pulchra is used traditionally as prophylactic against snake-bite, treatment of infected wounds and as anti-inflammatory. In this study, the behavioural effects of hydromethanolic of the aerial part extracts of Indigofera pulchra were investigated in mice. The results revealed that the extract significantly (p＜0.05) prolonged the onset and reduced the duration of sleep at the dose tested (200mg/kg). The extract significantly (p＜0.05) increased exploratory activity at the dose tested (400mg/kg). It produced no significantly motor coordination deficits in mice at the doses tested (100, 200 and 400mg/kg). The intraperitoneal median lethal dose in mice was 2,154 mg/kg while the preliminary phytochemical screening revealed the presence of tannins, saponins, steroids and flavonoids. This result suggests that hydromethanolic extract of Indigofera pulchra might contains biologically active principles that are stimulative in nature and lend pharmacological credence to the ethnomedical use of the plant.

並列關鍵字

Indigofera pulchra ； diazepam ； behavioral and motor coordination