Effects of Antioxidant Vitamin Combination on Electrolyte Status in Pregnancy

O. I. Iribhogbe ； J. E. Emordi ； B. O. Idonije ； U. Akpamu ； E. O. Nwoke ； A. Aigbiremolen

《British Journal of Pharmacology and Toxicology》 2卷1期 (2011/02) Pp. 21-26

摘要

It is a known fact that hypertension is associated with pregnancy. Several studies have reported a link between hypertension and a shift in serum electrolyte concentration. This study is designed to investigate the effect of antioxidant vitamin A, C and E bi- combination on electrolyte status in pregnancy. In a bid to investigate the above objective, varying combination of antioxidant vitamin A, C and E were administered to 70 pregnant Wister albino rats. These were assigned into two control groups treated with distilled H_2O and vehicle- tween-80 respectively and three cohorts (I, II and III) with four sub-groups each (n=5). Beginning from the 7^(th) day, test group I received a varying dose combination of vitamin A+C, group II vitamin A+E, and group III vitamin C+E respectively for 11 days. Results revealed a non significant reduction (p＞0.05) in serum Na^+ and Ca^(2+), and a significant change p＜0.05) in serum Cl^- and K^+ following Vit A+C administration when compared with control. The group treated with Vit A+E combination presented a non significant change in serum Na^+, Cl^-, K^+ and Ca^(2+) level. Vit C+E treated group presented a significant reduction (p＜0.05) in serum Na^+, K^+ and Ca^(2+) with no alteration in serum ClG. In conclusion, antioxidant vitamin A, C and E bi-combination ameliorates the reported high Na+ concentration in pregnancy and may be of significance as adjuvants in the management of hypertension in pregnancy. However, the importance of further research cannot be overemphasized.

關鍵字

Antioxidants ； bi-combination ； electrolytes ； hypertension ； pregnancy ； synergistic ； vitamins