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Adaptation of Adipokines in Polycystic Ovary Syndrome
並列摘要
Polycystic ovary syndrome (PCOS) is a common endocrine disease with multiple clinical manifestations, including obesity, insulin resistance, and hyperandrogenism. Adipokines such as adiponectin, leptin, and visfatin are specific hormones secreted by adipose tissue, and they may be involved in the pathogenesis of PCOS. Adiponectin plays a role in central reproductive endocrine axis and the ovary. Serum adiponectin levels are negatively correlated with insulin resistance and lower in PCOS women. Leptin regulates body fat storage and food-intake behavior. Serum leptin levels are positively correlated with body fat in both PCOS and healthy women. Visfatin has an insulinmimic effect but serum visfatin levels are generally higher in PCOS women. Further studies are needed to elucidate the mechanism between PCOS pathogenesis and adipokine adaptation.
延伸閱讀
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