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The Short-Term and Long-Term Effects of Stressors on the Acquisition of Cocaine-Induced Conditioned Place Preference
並列摘要
The short-term and long-term modulating effects of exposure to stressors on the acquisition of cocaine-induced conditioned place preference (CPP) were examined in this study. Unconditioned foot shock was used immediately before each conditioning of cocaine-induced CPP to study the short-term modulating effect of stress on the acquisition of cocaine-induced CPP. Nonetheless, a combined stress procedure was used 4 weeks prior to the cocaine-induced CPP to examine the long-term effect of stress on the acquisition of this memory. We found that foot shock stressor did not acutely affect cocaine-induced CPP as extremely low (2.5 mg/kg/conditioning) or high (10 mg/kg/conditioning) dose of cocaine was used as conditioning dosage. In contrast, foot shock stress significantly decreased cocaine (5 mg/kg/conditioning)-induced CPP. Interestingly, a combined unconditioned foot shock and restraint in water stressor drastically increased cocaine (5 mg/kg/conditioning)-induced CPP. The implication of the latter result is that pre-exposure to a potent stressor may enhance the appetitive effect of cocaine in a long-term manner.
延伸閱讀
- 劉冠伶（2013）。An Empirical Investigation of Academic Stress,Leisure Coping Strategies and Leisure Benefits〔碩士論文，朝陽科技大學〕。華藝線上圖書館。https://www.airitilibrary.com/Article/Detail?DocID=U0078-2712201314042202
- 劉冠伶、張瑞興、許吉越（2014）。An Empirical Investigation of Academic Stress, Leisure Coping Strategies and Leisure Benefits。休閒事業研究，12(2)，17-28。https://doi.org/10.6746/LIR.201406_12(2).0002
- 陳巧雲（2018）。Using Event-Related Spectral Perturbations to Examine how Adolescents with Drug Abuse Respond to Social Rejection。青少年犯罪防治研究期刊，10(2)，123-156。https://doi.org/10.29751/JRDP.201812_10(2).0004
- 楊士隆、李思賢、鄭凱寶、顧以謙、劉子瑄、溫梅君（2017）。The experience of drug abuse between deferred prosecution and compulsory treatment for second-class drug abuser。藥物濫用防治，2(4)，1-3+5-31。https://doi.org/10.6645/JSAR.2017.2.4.1
- 邱芬凌（2009）。A Study of Drug Abuse From The Influence of Characters,Relationships of Family and Social Environment Factors〔碩士論文，國立屏東科技大學〕。華藝線上圖書館。https://www.airitilibrary.com/Article/Detail?DocID=U0042-0207201015182311