Objective: To determine the effects of early pulmonary recondition therapy in critically ill patients with mechanical ventilation in the intensive care unit. Methods: We enrolled all ICU patients who received mechanical ventilation≥3 days during the period between August, 2010 and November, 2010 and we also collected patient data from August, 2009 to November, 2009 as a comparison. The pulmonary recondition therapy included airway clearance, breathing retraining, and limb muscle training. Results: Over a 4-month period we applied the recondition therapy protocol, 102 patients received this therapy. We found this protocol improved the weaning rate from 52% to 70.6% (p-0.0009), reduced the duration of mechanical ventilation from 15 days to 10.7 days (p=0.0468), shortened the hospital stay from 29.6 days to 25.9 days (p=0.0439), and reduced mortality from 43.3% to 22.5% (p=0.0008). Conclusion: Early pulmonary recondition therapy in critically ill ventilated patients can improve the weaning rate, ventilation time, hospital stay, and obtain the family's trust and satisfaction of the medical team.