葡萄糖胺治療骨關節炎之效果：案例實證

Glucosamine Use in the Management of Osteoarthritis: Evidence-Based Medicine

傅鈺翔(Yu-Hsiang Fu) ； 張震鴻(Chen-Hung Chang) ； 林彥輝(Yen-Hui Lin) ； 胡儷馨(Li-Shin Hu) ； 徐永年(Yuan-Nian Hsu) ； 徐錦池(Jiin-Chyr Hsu)

《醫學與健康期刊》 2卷1期附冊 (2013/09) Pp. 49-54

摘要

關節炎是常見的肌肉骨骼系統疾病之一，各類營養補充品也常用於膝關節或髖關節等退行性骨關節疾病。葡萄糖胺治療退行性關節炎的角色長期以來一直是有爭議的，為了進一步了解硫酸鹽葡萄糖胺和鹽酸鹽葡萄糖胺，在治療退行性骨關節炎的好處和風險，本文嚴格評讀最佳證據等級文獻，系統性回顧，根據實證醫學的五個步驟，討論包括提出問題、搜尋文獻、嚴格評讀、臨床應用及成效評估。總體而言，葡萄糖胺治療骨關節炎並無顯著療效。透個實證醫學的五個步驟，可以幫助臨床決策之形成。

關鍵字

葡萄糖胺 ； 退化性關節炎 ； 骨關節炎 ； 實證醫學

並列摘要

Osteoarthritis (OA) is one of the prevalent musculoskeletal diseases. Nutritional supplements are commonly used for a variety of musculoskeletal conditions, including knee and hip degenerative joint disease. The roles of glucosamine therapy for patients with degenerative joint disease have long been debated. In order to further understand the benefits and risks of glucosamine sulfate and Glucosamine hydrochloride for degenerative joint disease, this paper had critically analyzed the best available evidence, systematic reviews, based on the evidence-based study methods including asking, acquiring, appraising, applying and auditing. Overall, the conclusion of this study would suggest that compared with placebo, glucosamine do not reduce joint pain or have an impact on narrowing of joint space. This helps clinicians predict whether a treatment will do more good than harm.

並列關鍵字

Glucosamine ； Degenerateive Joint Disease ； Osteoarthritis ； Evidence-based medicine