The purpose of this study was to explore the relationship between conscientiousness and creativity under explicit instruction (EI). After performing conscientiousness scales, 50 participants were randomly assigned to an EI group or a control group. We then applied a creative imagination task involving 3 indicators (i.e., originality, practicality, and beyond reality) to measure the creative imagination performance of participants. The results showed that under the control condition, conscientiousness negatively related to originality and beyond reality, but not practicality. The findings also indicated that the EI method of future thinking increased the performances of practicality and beyond reality, but not originality. In conclusion, conscientiousness negatively relates to creative thinking; however, the relationship between them can be positive under the condition of EI.