新引進藥用植物VUKA（Mondia whitei L.）對小鼠餵飼之安全性評估

Safety Evaluation of Feeding a Newly Introduced Medicinal Plant VUKA (Mondia whitei L.) to Mice

郭肇凱(Xhao-Kai Kuo) ； 張隆仁(Long-Zen Chang) ； 陳榮五(Yung-Wu Chen) ； 廖俊旺(Jiunn-Wang Liao)

《臺中區農業改良場研究彙報》 91期 (2006/06) Pp. 21-29

https://doi.org/10.6956/BTDAIS.200606.0021

摘要

For the purpose to investigate the safety of utilizing VUKA (Mondia whitei L.), we processed the acute oral toxicity test in ICR mice. There was no mouse dead after given with VUKA extracts during the time course, so the LD50 of water-extracted and freeze-dried powder of VUKA was estimated over 15 g/kg body weight for mice. No significant lesions of brain, heart, liver, kidney, spleen and thymus were found at gross and histopathological observation in the treated mice. Hematological parameters included of WBC, RBC, HGB, HCT, MCV, MCH, MCHC and PLT values were as normal as control. Besides, serum biochemistry changes in liver and renal function included of ALT, AST and creatinine values had no significant difference (p＞0.05) with control.

關鍵字

急性毒性 ； 半致死劑量（LD50）

並列摘要

For the purpose to investigate the safety of utilizing VUKA (Mondia whitei L.), we processed the acute oral toxicity test in ICR mice. There was no mouse dead after given with VUKA extracts during the time course, so the LD50 of water-extracted and freeze-dried powder of VUKA was estimated over 15 g/kg body weight for mice. No significant lesions of brain, heart, liver, kidney, spleen and thymus were found at gross and histopathological observation in the treated mice. Hematological parameters included of WBC, RBC, HGB, HCT, MCV, MCH, MCHC and PLT values were as normal as control. Besides, serum biochemistry changes in liver and renal function included of ALT, AST and creatinine values had no significant difference (p＞0.05) with control.

並列關鍵字

VUKA (Mondia whitei) ； acute toxicity ； semi-mortality (LD50)