- 期刊
- OpenAccess
Arterial Spin-Labeling MRI of Neonates: Quantification of Cerebral Blood Flow With Individualized Parameters
摘要
PURPOSE. We aimed to compare cerebral blood flow (CBF) quantification when adopting default adult parameters and CBF quantification when adopting individualized neonatal parameters. MATERIALS AND METHODS. Arterial spin-labeling perfusion magnetic resonance studies of 32 neonates were analyzed. CBF quantifications were performed with offline calculation (Mpld) adopting default adult parameters to demonstrate the measurement results of Functool software, and these were compared to measurements resulting from the use of 3 different calculations (M1, M2, and M3) that adopted the subject-specific parameters of neonates, specifically the T1 of blood and the blood-brain partition coefficient. Co-registration and gray matter (GM) segmentation were performed to extract cerebral GM-CBF values. We assessed the agreement of CBF measurements between Mpld, M1, M2, and M3 by using Bland-Altman analysis. RESULTS. Negative mean differences were found in Mpld minus M1 (mean difference = 6.115 mL/100g/min [29.16%]), Mpld minus M2 (4.782 [21.44%]), and Mpld minus M3 (6.879 [34.04%]). CONCLUSION. In neonates, quantifying CBF by adopting adult parameters results in a 21.44%-34.04% overestimation of CBF.
延伸閱讀
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