- 期刊
以核磁共振光譜研究磷酸水解酶抑制蛋白的結構
Structural Study on the Inhibitor Proteins of Protein Phosphatase 1 by NMR
並列摘要
Human inhibitor 1 is a heat- and acid- stable phosphor-protein, which regulates a diversity of cellular processes through the inhibition of protein phosphatase 1 (PP1). After phosphorylation of Thr35 by protein kinase A, human inhibitor 1 is converted into a potent inhibitor of protein phosphatase 1. In order to gain insight to the interaction between inhibitor-1 and PP1, we have used multidimensional heteronuclear NMR techniques to elucidate the structural properties of inhibitor-1. We have assigned full resonances of inhibitor 1. The secondary short helices spanning from 24- 28, 81-86, 103-109, and 127-131. These structural data can provide as a model to predict the interaction of protein phosphatase and its endogeneous inhibitor proteins.
延伸閱讀
- Li, F. Y. (2009). 以磷酸化蛋白質譜鑑定乳癌激酶之受質 [master's thesis, National Taiwan University]. Airiti Library. https://doi.org/10.6342/NTU.2009.10175
- 黃靖雅（2013）。以質譜定量技術分析磷酸化蛋白體研究Sorafenib後天抗藥性機制〔碩士論文，國立臺灣大學〕。華藝線上圖書館。https://doi.org/10.6342/NTU.2013.11170
- 吳宗憲（2013）。探討重組第一型蛋白質磷酸水解酶與磷酸化第一型抑制蛋白間之交互作用〔碩士論文，國立中正大學〕。華藝線上圖書館。https://www.airitilibrary.com/Article/Detail?DocID=U0033-2110201613554211
- 黃太煌、陳金榜、林達顯（1997）。NMR Spectroscopy and Structures of Proteins in the Aqueous Solution。化學，55(3)，77-86。https://doi.org/10.6623/chem.1997035
- Cheng, C. S. (2006). Structure, Function and Application of Plant Nonspecific Lipid Transfer Protein [doctoral dissertation, National Tsing Hua University]. Airiti Library. https://doi.org/10.6843/NTHU.2006.00010