Background: To study the neuromuscular inter action between mivacurium and esmolol, we compared the neuromuscular actions of the ED_(90) dose of mivacurium both in the absence and presence of esmolol infusion. Methods: Twelve rats were anesthetized with urethane. Train-of-four stimulation was applied every 12 s to the sciatic nerve, and the electromyogram (EMG) response of the anterior tibial muscle was measured. Results: The ED_(50) and ED_(90) of mivacurium in rats were 144 ± 7.3 μg/kg and 197 ± 7.7μg/kg, respectively. The maximal EMG depression produced by ED_(50) of mivacurium decreased significantly with esmolol treatment from 88.2 ± 2.7% to 83.1 ± 2.6% after esmolol infusion (p < 0.05). The onset time for 75% EMG depression was much shorter for control (44 ± 6.3 s) than that of esmolol treatment (78.2 ± 2.4 s; p < 0.05). There was no difference between their duration. Conclusions: The results of this study demonstrated that esmolol does not potentiate the neuromuscular effect of mivacurium but antagonize the maximal neuromuscular block and decrease its onset time in rats.
背景:本研究是關於mivacurium和esmolol之間神經肌肉作用的關係。我們先求出大白鼠的mivacurium百分之九十有效劑量(ED_(90)),再比較此劑量的mivacurium在注射esmolol之前和之後所產生的神經肌肉作用的結果。方法:十二隻用urethane麻醉之大白鼠,以每12秒一次的Train-of-Four(TOF)刺激器置於坐骨神經,同時記錄前脛肌之肌電圖(EMG)。結果:Mivacurium原來的ED_(50)和ED_(90)分別為144 ± 7.3μg/kg和197 ± 7.7μg/kg。由ED_(90)的mivacurium所產生的肌電圖抑制有顯著的差異,其神經肌肉最大阻斷效應(maximal block)由注射的esmolol之前的88.2 ± 2.7%減少為注射後的83.1 ± 2.6%,p值小於0.05。而作用起始時間(onset time)在注射esmolol之後也明顯變長(由44 ± 6.3秒延長至78.2 ± 2.4秒,p<0.05)。至於作用時間(duration)在整個實驗中則無顯著的差異。結論:Mivacurium和esmolol之間的藥理反應並無加強作用。
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