The inheritance dilemma of family businesses has become an important issue for Chinese and even global family businesses. Buddhist organizations and family businesses are facing the problem of long-term inheritance and modernization. Fo Guang shan promotes and practices the spirit of Humanistic Buddhism and the success of Buddhist modernization. Master Hsing Yun's wisdom is worthy of reference for family companies to deal with succession issues. After analyzing the possibility and necessity of studying the inheritance of family business from the perspective of Buddhism, this article discusses the methods of Zen Buddhism in human Buddhism from the aspects of holding virtue, meditation, letting down, focusing, and initiating the heart. The possible inspiration and role of the successful inheritance of the family business, hoping that the nectar of Humanistic Buddhism can help the family business to better complete the intergenerational replacement.