- 期刊
- OpenAccess
SGLT2 Inhibitor-Associated Euglycemic Diabetic Ketoacidosis in Eight Cases in a Medical Center in Taiwan
摘要
Background. Since the use of SGLT2 inhibitor was initially approved in 2013 by the US Food and Drug Administration, SGLT2 inhibitors (SGLT2i) have become a new mainstay treatment for type 2 diabetes mellitus. In Taiwan, SGLT-2i was marketed since 2014 and approved to be a second-line OAD for type 2 diabetes. Several case reports and systemic reviews have been conducted worldwide regarding SGLT2i-associated diabetic ketoacidosis. With this case series of eight patients, we aimed to investigate the event rate of euglycemic diabetic ketoacidosis associated with SGLT2i in the Taiwanese population. Methods and Results. We collected eight cases of SGLT2i-associated euglycemic diabetic ketoacidosis in our hospital from July 2016 to April 2018. SGLT2i, including empagliflozin (3133) and dapagliflozin (1702), were administered in 4835 patients. The event rate is approximately 0.17%. Conclusion. Although SGLT2i-associated euglycemic diabetic ketoacidosis is rare, the clinical physician should be aware of this uncommon complication.
延伸閱讀
- Hsueh, H. Y., Weng, C. T., & Liu, M. F. (2015). Clinical Characteristics of Patients with IgG4-Related Disease: The Experience of a Medical Center in Southern Taiwan. Formosan Journal of Rheumatology, 29(1), 24-31. https://doi.org/10.6313/FJR.2015.29(01).04
- 陳舒亭（2013）。Prescribing quality of oral hypoglycemic agents among newly treated diabetics in Taiwan〔碩士論文，國立臺灣大學〕。華藝線上圖書館。https://doi.org/10.6342/NTU.2013.01734
- Wang, C. H., Fang, T. C., Hsu, B. G., Lin, C. C., & Shen, T. W. (2007). The Prevalence of Metabolic Syndrome in a Group of Patients Receiving Long-Term Hemodialysis in Eastern Taiwan. Acta Nephrologica, 21(3), 201-205. https://www.airitilibrary.com/Article/Detail?DocID=10131671-200710-21-3-201-205-a
- Chen, C. Y., Chen, P. H., Yeh, H. W., Chiang, M. T., Chiu, K. C., & Shieh, Y. S. (2012). Frequency and Distribution of Idiopathic Osteosclerosis in Diabetic Patients-a Pilot Study in Taiwan. Journal of Medical Sciences, 32(4), 165-169. https://doi.org/10.6136/JMS.2012.32(4).165
- Yang, A. Y., & Chen, H. C. (2020). Effectiveness and Renal Safety of SGLT-2 Inhibitors in Elderly and Non-Elderly Patients with Type 2 Diabetes. Formosan Journal of Endocrinology and Metabolism, (), 1-11. https://doi.org/10.6856/FJEM.202212/PP.0001