In the winter of 2018, there were many times of regional air pollution episodes in Eastern China, which had an deep adverse impact on social production and people's lives. This paper selects a typical regional air pollution episode from January 14 to January 23, 2018 in Eastern China. By using the air pollutant PM2.5 monitoring data, the spatial distribution and temporal variation characteristics of air pollutants are analyzed, which will be good for providing technical reference for subsequent pollution control.