In human life, the continuity of the development of historical buildings and regional residential buildings is very important. Traditional residential building is an important material carrier of regional culture, and regional culture determines the development trend of traditional residential building. Tradition is the genetic gene of regional culture. In order to reflect the local culture, the most direct is to reflect it in the residential buildings. In modern residential design, the use of traditional culture has become an important direction of interior design innovation. Every living area we live in depends on the urban environment that has been designed or built around it, so it is impossible to separate the two. Under the existing social environment mode, people also pay more attention to traditional culture. Starting from the inheritance and interpretation of traditional characteristic culture, this paper discusses the application in modern new residential design. Explore the future development trend and design methods of regional residential buildings, and explain the cultural language contained in regional residential buildings.