In order to solve the machining difficulty of titanium alloy material, improve the machining surface quality and improve tool wear, orthogonal experimental design method was used to design the milling experiment to study the influence of cutting parameters on the machining effect of the material in the process of machining. In this paper, a prediction model of milling force in three directions was established. Finite element simulation analysis was carried out on two groups of specific experimental data by USING ABAQUS finite element simulation software and the chip morphology was compared with this group of experimental data. The results show that the milling depth and milling width have little influence on the milling force, and the three direction milling force has inflection point at different milling speed and feed. The results of finite element simulation show that chip shape changes with the change of machining conditions, and the condition of sudden change of chip shape is similar to the test.