The mixed teaching mode based on SPOC is a new teaching mode that integrates MOOC and traditional teaching. Its main features highlight students' dominant position, teaching places are more diversified and three-dimensional, curriculum learning space is expanded, and personalized guidance to students is more prominent. This new teaching mode can effectively improve the effectiveness and pertinence of supply chain management, stimulate teachers' teaching potential and students' innovative thinking. The teaching mode based on SPOC has opened a new direction for the teaching reform of supply chain management.