左旋維他命C/蒙脫石複合材料之應用研究

Feasibility study of constructed L-ascorbic acid/montmorillonite composite for applications

張啟祐(Chi-Yu Chang)

指導教授 ： 李源弘

共同指導教授 ： 陳博彥

國立臺灣大學/工學院/材料科學與工程學研究所/碩士(2007年)

https://doi.org/10.6342/NTU.2007.10123

摘要

本實驗主要以一種新的低毒性高安定左旋維他命C複合物作可行性之應用分析，雖然文獻上提出使用硫代硫酸鈉可以有效的安定左旋維他命C，但是我們由實驗證明，硫代硫酸鈉與左旋維他命C複合後，卻會產生明顯的生物抑制性，故而加入無毒安全之天然蒙脫石，試圖使複合物毒性下降，使其具有高安定性低毒性之左旋維他命C複合物，以提升未來商業價值。由蒙脫石層間距變化發現到，左旋維他命C的添加將會影響到蒙脫石層間距的改變，而蒙脫石的遮蔽效應則會使左旋維他命C複合物成為安定且安全的材料，而在實驗中的複合物又以【MMT + 10 % LAA + 0.90 % Na2S2O3】 與 【MMT + 5 % LAA + 1.35 % Na2S2O3】毒性最低最為可行。

關鍵字

左旋維他命C ； 蒙脫石 ； 硫代硫酸鈉

並列摘要

This study tended to construct new L-ascorbic acid (LAA) composites in low toxicity and high stability for feasible application. Although literature revealed that sodium thiosulphate could stabilize the activity of LAA, our finding showed that the significant toxicity was provoked by the introduction of sodium thiosulphate. Thus, a safe-and-non-toxic material montmorillonite (MMT) was thus used to attenuate this toxicity and to sustain the stability of composites with economic feasibility for practical use. As the proton released from LAA promoted the increases of interlayer spacing of clay layers in MMT, the formation of stable-and-non-toxic LAA composites was resulted as indicated from toxicity assessment (i.e., yeast model) and stability tests. The composites of 【MMT + 10 % LAA + 0.90 % Na2S2O3】 and 【MMT + 5 % LAA + 1.35 % Na2S2O3】were found to be feasible for further applications.

並列關鍵字

L-ascorbic acid (LAA) ； montmorillonite ； Sodium thiosulfate

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