以環三聚藜烴和冠醚為基礎之籠狀分子 合成與鍵結研究

The Synthesis and Binding Test of CTV-based Molecular Container

朱佑洲(Yu-Chou Chu)

指導教授 ： 邱勝賢

國立臺灣大學/理學院/化學研究所/碩士(2011年)

https://doi.org/10.6342/NTU.2011.10701

摘要

我們合成了一個冠醚分子連結環三聚藜烴的膠囊狀主體分子。此主體分子雖同樣具有兩個環三聚藜烴的結構，但分子內空間相較於過去實驗室開發的此類主體分子的體積為狹小。我們希望利用此特性能夠帶來較特別的小分子辨識特性。希望在未來能夠找到合適的客體分子將它內鎖於此分子容器中。

關鍵字

環三聚藜烴

並列摘要

We have already reported the stepwise synthesis of a CTV-based molecular container from three copies of the same crown ether. We used this synthetic strategy to construct capsule-like molecular container with the two CTV units separated at shorter distances. We hope that this molecular container can display unique recognition property and facilitate the construction of its corresponding interlocked compounds in the future.

並列關鍵字

cyclotriveratrylene

參考文獻

1. Nicolaou, K. C; Vourloumis, D.; Winssinger, N.; Baran, P. S. Angew. Chem. Int. Ed. 2000, 39, 44–122.

2. Muller-Dethlefs, K.; Hobza, P. Chem. Rev. 2000, 100, 143–167.

3. (a) Ghadiri, M. R.; Granja; J. R.; Milligan, R. A.; McRee, D. E.; Khazanovich, N. Nature 1993, 366, 324–327. (b) Whitesides, G. M.; Simanek, E. E.; Mathias, J. P.; Seto, C. T.; Chin, D. N.; Mammen, M.; Gordon, D. M. Acc. Chem. Res. 1995, 28, 37–44. (c) Zimmerman, S. C.; Zeng, F.; Reichert, D. E. C.; Kolotuchin, S. V. Science 1996, 271, 1095–1098. (d) Mascal, M.; Hext, N. M.; Warmuth, R.; Moore, M. H.; Turkenburg, J. P. Angew. Chem. Int. Ed. 1996, 35, 2204–2206. (e) Sijbesma, R. P.; Beijer, F. H.; Brunsveld, L.; Folmer, B. J. B.; Hirschberg, J. H. K. K.; Lange, R. F. M.; Lowe, J. K. L.; Meijer, E. W. Science 1997, 278, 1601–1604. (f) Rebek, J., Jr. Acc. Chem. Res. 1999, 32, 278–286.

4. (a) Dougherty, D. A. Science 1996, 271, 163–168. (b) Ma, J. C.; Dougherty, D. A. Chem. Rev. 1997, 97, 1303–1324. (c) Gokel. G. W.; De Wall, S. L.; Meadows, E. S. Eur. J. Org. Chem. 2000, 17, 2967–2978. (d) Gokel, G. W.; Barbour, L. J.; Ferdani, R.; Hu, J. Acc. Chem. Rev. 2002, 35, 878–886.

5. (a) Hunter, C. A.; Sanders, L. K. M. J. Am. Chem. Soc. 1990, 112, 5525–5534. (b) Philip, D.; Slawin, A. M. Z.; Spencer, N.;Stoddart, J. F.; Williams, D. J. J. Chem. Soc. Chem. Commum. 1991, 1584–1586. (c) Hamilton, D. G.; Davies, J. E.; Prodi, L.; Sanders, J. K. M. Chem. Eur. J. 1998, 4, 608–620.